PRKCSH Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 9 A3|9 8.04 cM
Cellular Component:  endoplasmic reticulum; glucosidase II complex; intracellular membrane-bounded organelle
Molecular Function:  calcium ion binding; ion channel binding; metal ion binding; phosphoprotein binding; protein binding; protein kinase C binding; RNA binding
Biological Process:  in utero embryonic development; liver development; N-glycan processing; negative regulation of neuron projection development; nitrogen compound metabolic process; protein heterooligomerization
Reference #:  O08795 (UniProtKB)
Alt. Names/Synonyms: 80K-H; 80K-H protein; alpha glucosidase II, beta-subunit; carbohydrate processing enzyme of the endoplasmic reticulum; GLU2B; Glucosidase 2 subunit beta; glucosidase II beta-subunit; Glucosidase II subunit beta; hepatocystin; PKCSH; Prkcsh; Protein kinase C substrate 60.1 kDa protein heavy chain; protein kinase C substrate 80K-H
Gene Symbols: Prkcsh
Molecular weight: 58,793 Da
Basal Isoelectric point: 4.41  Predict pI for various phosphorylation states
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PRKCSH

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene