PRKCSH Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 19p13.2
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum lumen; glucosidase II complex; intracellular membrane-bounded organelle
Molecular Function:  calcium ion binding; phosphoprotein binding; protein binding; protein kinase C binding; transmembrane transporter binding
Biological Process:  intracellular signal transduction; liver development; N-glycan processing
Disease: Polycystic Liver Disease
Reference #:  P14314 (UniProtKB)
Alt. Names/Synonyms: 80K-H protein; advanced glycation end-product receptor 2; AGE-binding receptor 2; AGE-R2; G19P1; GIIB; GLU2B; Glucosidase 2 subunit beta; Glucosidase II subunit beta; glucosidase II, beta subunit; hepatocystin; PCLD; PCLD1; PKCSH; PLD1; PRKCSH; Protein kinase C substrate 60.1 kDa protein heavy chain; protein kinase C substrate 80K-H; protein kinase C substrate, 80 Kda protein; VASAP-60
Gene Symbols: PRKCSH
Molecular weight: 59,425 Da
Basal Isoelectric point: 4.33  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein