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PRKCSH
Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 19p13.2 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum lumen; glucosidase II complex; intracellular membrane-bounded organelle
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Molecular Function:
calcium ion binding; phosphoprotein binding; protein binding; protein kinase C binding; transmembrane transporter binding
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Biological Process:
intracellular signal transduction; liver development; N-glycan processing
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Disease: Polycystic Liver Disease
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Reference #:
P14314
(UniProtKB)
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Alt. Names/Synonyms: 80K-H protein; advanced glycation end-product receptor 2; AGE-binding receptor 2; AGE-R2; G19P1; GIIB; GLU2B; Glucosidase 2 subunit beta; Glucosidase II subunit beta; glucosidase II, beta subunit; hepatocystin; PCLD; PCLD1; PKCSH; PLD1; PRKCSH; Protein kinase C substrate 60.1 kDa protein heavy chain; protein kinase C substrate 80K-H; protein kinase C substrate, 80 Kda protein; VASAP-60
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Gene Symbols: PRKCSH
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Molecular weight:
59,425 Da
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Basal Isoelectric point:
4.33
Predict pI for various phosphorylation states
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