Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; Cytoskeletal
Chromosomal Location of human Ortholog: 17q21.31
Cellular Component:  axolemma; axon; axon cytoplasm; cell body; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; dendrite; dendritic spine; extracellular region; glial cell projection; growth cone; main axon; membrane; membrane raft; microtubule; microtubule cytoskeleton; mitochondrion; neurofibrillary tangle; neuron projection; neuronal cell body; nuclear periphery; nuclear speck; nucleus; plasma membrane; somatodendritic compartment; tubulin complex
Molecular Function:  actin binding; apolipoprotein binding; DNA binding; double-stranded DNA binding; dynactin binding; enzyme binding; histone-dependent DNA binding; Hsp90 protein binding; identical protein binding; lipoprotein particle binding; microtubule binding; microtubule lateral binding; minor groove of adenine-thymine-rich DNA binding; phosphatidylinositol binding; phosphatidylinositol bisphosphate binding; protein binding; protein kinase binding; protein phosphatase 2A binding; protein-folding chaperone binding; protein-macromolecule adaptor activity; RNA binding; sequence-specific DNA binding; SH3 domain binding; single-stranded DNA binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; amyloid fibril formation; astrocyte activation; axon development; axonal transport; axonal transport of mitochondrion; cell-cell signaling; cellular response to brain-derived neurotrophic factor stimulus; cellular response to heat; cellular response to nerve growth factor stimulus; cellular response to reactive oxygen species; central nervous system neuron development; cytoplasmic microtubule organization; DNA damage response; generation of neurons; internal protein amino acid acetylation; intracellular distribution of mitochondria; memory; microglial cell activation; microtubule cytoskeleton organization; microtubule polymerization; negative regulation of establishment of protein localization to mitochondrion; negative regulation of gene expression; negative regulation of kinase activity; negative regulation of mitochondrial fission; negative regulation of mitochondrial membrane potential; negative regulation of tubulin deacetylation; neurofibrillary tangle assembly; neuron projection development; plus-end-directed organelle transport along microtubule; positive regulation of axon extension; positive regulation of diacylglycerol kinase activity; positive regulation of microtubule polymerization; positive regulation of neuron death; positive regulation of protein localization; positive regulation of protein localization to synapse; positive regulation of superoxide anion generation; protein polymerization; regulation of autophagy; regulation of calcium-mediated signaling; regulation of cellular response to heat; regulation of chromosome organization; regulation of long-term synaptic depression; regulation of microtubule cytoskeleton organization; regulation of microtubule polymerization; regulation of microtubule polymerization or depolymerization; regulation of mitochondrial fission; regulation of synaptic plasticity; response to lead ion; rRNA metabolic process; stress granule assembly; supramolecular fiber organization; synapse organization
Disease: Frontotemporal Dementia; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related; Parkinson Disease, Late-onset; Parkinson-dementia Syndrome; Pick Disease Of Brain; Supranuclear Palsy, Progressive, 1
Reference #:  P10636 (UniProtKB)
Alt. Names/Synonyms: DDPAC; FLJ31424; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPT; MAPTL; MGC138549; microtubule associated protein tau; Microtubule-associated protein tau; MSTD; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU
Gene Symbols: MAPT
Molecular weight: 78,928 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Microtubule Dynamics  |  Regulation of P38 MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene