ENTH
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. Belongs to the epsin family. Ubiquitously expressed at low to intermediate levels. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
Chromosomal Location of mouse Ortholog: 11|11 B1.1 |
Cellular Component:
clathrin vesicle coat; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; endosome; Golgi apparatus; intracellular membrane-bounded organelle; membrane; nucleoplasm; plasma membrane
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Molecular Function:
clathrin binding; lipid binding; phospholipid binding
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Biological Process:
clathrin coat assembly; endocytosis
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Reference #:
Q99KN9
(UniProtKB)
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Alt. Names/Synonyms: AI642036; AW537616; C530049I24Rik; Clathrin interactor 1; Clint1; Enth; ENTH domain containing protein; Enthoprotin; Epn4; Epnr; epsin 4; Epsin-4; Epsin-related protein; EpsinR; F630206G17Rik; Kiaa0171; mKIAA0171; OTTMUSP00000005627
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Gene Symbols: Clint1
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Molecular weight:
68,513 Da
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Basal Isoelectric point:
5.88
Predict pI for various phosphorylation states
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