ENTH Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. Belongs to the epsin family. Ubiquitously expressed at low to intermediate levels. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11|11 B1.1
Cellular Component:  clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; Golgi apparatus; intracellular membrane-bounded organelle; membrane; nucleoplasm
Molecular Function:  clathrin binding; lipid binding
Biological Process:  clathrin coat assembly; endocytosis; vesicle-mediated transport
Reference #:  Q99KN9 (UniProtKB)
Alt. Names/Synonyms: AI642036; AW537616; C530049I24Rik; Clathrin interactor 1; Clint1; Enth; ENTH domain containing protein; Enthoprotin; Epn4; Epnr; epsin 4; Epsin-4; Epsin-related protein; EpsinR; F630206G17Rik; Kiaa0171; mKIAA0171; OTTMUSP00000005627
Gene Symbols: Clint1
Molecular weight: 68,513 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Select Structure to View Below

ENTH

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene