|
ENTH
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. Belongs to the epsin family. Ubiquitously expressed at low to intermediate levels. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 5q33.3 |
|
Cellular Component:
clathrin vesicle coat; cytosol; endosome; Golgi apparatus; intracellular membrane-bounded organelle; nucleoplasm; perinuclear region of cytoplasm; plasma membrane
|
|
Molecular Function:
clathrin binding; phospholipid binding; protein binding
|
|
Biological Process:
endocytosis
|
|
Disease: Schizophrenia 1
|
|
Reference #:
Q14677
(UniProtKB)
|
|
Alt. Names/Synonyms: clathrin interacting protein localized in the trans-Golgi region; Clathrin interactor 1; Clathrin-interacting protein localized in the trans-Golgi region; Clint; CLINT1; ENTH; Enthoprotin; EPN4; EPNR; epsin 4; Epsin-4; Epsin-related protein; EpsinR; FLJ46753; KIAA0171
|
|
Gene Symbols: CLINT1
|
|
Molecular weight:
68,259 Da
|
|
Basal Isoelectric point:
6.01
Predict pI for various phosphorylation states
|
