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ENTH
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. Belongs to the epsin family. Ubiquitously expressed at low to intermediate levels. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 5q33.3 |
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Cellular Component:
clathrin-coated vesicle; cytosol; Golgi apparatus; intracellular membrane-bounded organelle; nucleoplasm; perinuclear region of cytoplasm
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Molecular Function:
clathrin binding; lipid binding; protein binding
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Biological Process:
clathrin coat assembly; endocytosis
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Disease: Schizophrenia 1
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Reference #:
Q14677
(UniProtKB)
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Alt. Names/Synonyms: clathrin interacting protein localized in the trans-Golgi region; Clathrin interactor 1; Clathrin-interacting protein localized in the trans-Golgi region; Clint; CLINT1; ENTH; Enthoprotin; EPN4; EPNR; epsin 4; Epsin-4; Epsin-related protein; EpsinR; FLJ46753; KIAA0171
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Gene Symbols: CLINT1
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Molecular weight:
68,259 Da
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Basal Isoelectric point:
6.01
Predict pI for various phosphorylation states
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