ENTH Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. Belongs to the epsin family. Ubiquitously expressed at low to intermediate levels. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 5q33.3
Cellular Component:  clathrin vesicle coat; cytosol; endosome; Golgi apparatus; intracellular membrane-bounded organelle; nucleoplasm; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  clathrin binding; phospholipid binding; protein binding
Biological Process:  endocytosis
Disease: Schizophrenia 1
Reference #:  Q14677 (UniProtKB)
Alt. Names/Synonyms: clathrin interacting protein localized in the trans-Golgi region; Clathrin interactor 1; Clathrin-interacting protein localized in the trans-Golgi region; Clint; CLINT1; ENTH; Enthoprotin; EPN4; EPNR; epsin 4; Epsin-4; Epsin-related protein; EpsinR; FLJ46753; KIAA0171
Gene Symbols: CLINT1
Molecular weight: 68,259 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein