SOD2 Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Mitochondrial; Oxidoreductase
Chromosomal Location of mouse Ortholog: 17 A1|17 8.75 cM
Cellular Component:  cytoplasm; mitochondrial matrix; mitochondrial nucleoid; mitochondrion
Molecular Function:  DNA binding; enzyme binding; identical protein binding; manganese ion binding; metal ion binding; oxidoreductase activity; oxygen binding; protein binding; superoxide dismutase activity
Biological Process:  acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure; age-dependent response to oxidative stress; age-dependent response to reactive oxygen species; apoptotic mitochondrial changes; detection of oxygen; erythrophore differentiation; glutathione metabolic process; heart development; hemopoiesis; hydrogen peroxide biosynthetic process; hydrogen peroxide metabolic process; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to oxidative stress; iron ion homeostasis; liver development; locomotory behavior; mitochondrion organization; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of fat cell differentiation; negative regulation of fibroblast proliferation; negative regulation of neuron apoptotic process; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of vascular smooth muscle cell proliferation; neuron development; oxidation-reduction process; oxygen homeostasis; positive regulation of cell migration; positive regulation of nitric oxide biosynthetic process; positive regulation of vascular associated smooth muscle cell apoptotic process; positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching; post-embryonic development; protein homooligomerization; protein homotetramerization; regulation of blood pressure; regulation of catalytic activity; regulation of mitochondrial membrane potential; regulation of transcription by RNA polymerase II; release of cytochrome c from mitochondria; removal of superoxide radicals; respiratory electron transport chain; response to activity; response to axon injury; response to drug; response to gamma radiation; response to hydrogen peroxide; response to hyperoxia; response to nutrient levels; response to oxidative stress; response to reactive oxygen species; response to superoxide; superoxide anion generation; superoxide metabolic process; vasodilation
Reference #:  P09671 (UniProtKB)
Alt. Names/Synonyms: manganese SOD; manganese superoxide dismutase; MGC6144; MnSOD; Sod; Sod-2; Sod2; SODM; superoxide dismutase 2, mitochondrial; Superoxide dismutase [Mn], mitochondrial
Gene Symbols: Sod2
Molecular weight: 24,603 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene