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SOD2
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.15.1.1; Mitochondrial; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 17 A1|17 8.75 cM |
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Cellular Component:
mitochondrial matrix; mitochondrial nucleoid; mitochondrion
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Molecular Function:
DNA binding; enzyme binding; identical protein binding; manganese ion binding; metal ion binding; oxidoreductase activity; oxygen binding; protein binding; superoxide dismutase activity
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Biological Process:
acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure; apoptotic mitochondrial changes; cellular response to oxidative stress; detection of oxygen; erythrophore differentiation; glutathione metabolic process; heart development; hemopoiesis; hydrogen peroxide biosynthetic process; hydrogen peroxide metabolic process; intracellular oxygen homeostasis; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to oxidative stress; liver development; locomotory behavior; mitochondrion organization; multicellular organismal-level iron ion homeostasis; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of fat cell differentiation; negative regulation of fibroblast proliferation; negative regulation of membrane hyperpolarization; negative regulation of neuron apoptotic process; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of vascular associated smooth muscle cell proliferation; neuron development; positive regulation of cell migration; positive regulation of hydrogen peroxide biosynthetic process; positive regulation of nitric oxide biosynthetic process; positive regulation of vascular associated smooth muscle cell apoptotic process; positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching; post-embryonic development; protein homotetramerization; regulation of blood pressure; regulation of catalytic activity; regulation of mitochondrial membrane potential; regulation of transcription by RNA polymerase II; release of cytochrome c from mitochondria; removal of superoxide radicals; respiratory electron transport chain; response to activity; response to axon injury; response to gamma radiation; response to hydrogen peroxide; response to hyperoxia; response to nutrient levels; response to oxidative stress; response to reactive oxygen species; response to superoxide; response to xenobiotic stimulus; sensory perception of sound; superoxide anion generation; superoxide metabolic process; vasodilation
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Reference #:
P09671
(UniProtKB)
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Alt. Names/Synonyms: manganese SOD; manganese superoxide dismutase; MGC6144; MnSOD; Sod; Sod-2; Sod2; SODM; superoxide dismutase 2, mitochondrial; Superoxide dismutase [Mn], mitochondrial
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Gene Symbols: Sod2
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Molecular weight:
24,603 Da
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Basal Isoelectric point:
8.8
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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