SOD2 Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the iron/manganese superoxide dismutase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 6q25.3
Cellular Component:  mitochondrial matrix; mitochondrion
Molecular Function:  identical protein binding; manganese ion binding; superoxide dismutase activity
Biological Process:  acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure; age-dependent response to reactive oxygen species; cellular response to oxidative stress; interleukin-12-mediated signaling pathway; negative regulation of cell proliferation; negative regulation of neuron apoptotic process; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of vascular smooth muscle cell proliferation; oxidation-reduction process; oxygen homeostasis; positive regulation of cell migration; positive regulation of vascular associated smooth muscle cell apoptotic process; positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching; protein homotetramerization; regulation of blood pressure; regulation of transcription by RNA polymerase II; release of cytochrome c from mitochondria; removal of superoxide radicals; response to superoxide; superoxide metabolic process
Disease: Microvascular Complications Of Diabetes, Susceptibility To, 6
Reference #:  P04179 (UniProtKB)
Alt. Names/Synonyms: indophenoloxidase B; IPOB; manganese-containing superoxide dismutase; mangano-superoxide dismutase; Mn superoxide dismutase; MNSOD; MVCD6; SOD2; SODM; superoxide dismutase 2, mitochondrial; Superoxide dismutase [Mn], mitochondrial
Gene Symbols: SOD2
Molecular weight: 24,750 Da
Basal Isoelectric point: 8.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene