SOD2 Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.15.1.1; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 6q25.3
Cellular Component:  mitochondrial matrix; mitochondrion
Molecular Function:  identical protein binding; manganese ion binding; superoxide dismutase activity
Biological Process:  acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure; age-dependent response to reactive oxygen species; cellular response to oxidative stress; interleukin-12-mediated signaling pathway; negative regulation of cell proliferation; negative regulation of neuron apoptotic process; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of vascular smooth muscle cell proliferation; oxidation-reduction process; oxygen homeostasis; positive regulation of cell migration; positive regulation of vascular associated smooth muscle cell apoptotic process; positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching; protein homotetramerization; regulation of blood pressure; regulation of transcription by RNA polymerase II; release of cytochrome c from mitochondria; removal of superoxide radicals; response to superoxide; superoxide metabolic process
Disease: Microvascular Complications Of Diabetes, Susceptibility To, 6
Reference #:  P04179 (UniProtKB)
Alt. Names/Synonyms: indophenoloxidase B; IPOB; manganese-containing superoxide dismutase; mangano-superoxide dismutase; Mn superoxide dismutase; MNSOD; MVCD6; SOD2; SODM; superoxide dismutase 2, mitochondrial; Superoxide dismutase [Mn], mitochondrial
Gene Symbols: SOD2
Molecular weight: 24,750 Da
Basal Isoelectric point: 8.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SOD2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene