FETUA Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. Belongs to the fetuin family. Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q27.3
Cellular Component:  endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi apparatus; platelet alpha granule lumen; secretory granule lumen
Molecular Function:  cysteine-type endopeptidase inhibitor activity; kinase inhibitor activity
Biological Process:  acute-phase response; cellular protein metabolic process; negative regulation of bone mineralization; negative regulation of insulin receptor signaling pathway; negative regulation of kinase activity; neutrophil degranulation; pinocytosis; platelet degranulation; positive regulation of phagocytosis; post-translational protein modification; regulation of bone mineralization; regulation of inflammatory response; skeletal system development
Disease: Alopecia-mental Retardation Syndrome 1
Reference #:  P02765 (UniProtKB)
Alt. Names/Synonyms: A2HS; AHS; AHSG; alpha 2-HS glycoprotein; Alpha-2-HS-glycoprotein; Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B; Alpha-2-Z-globulin; APMR1; Ba-alpha-2-glycoprotein; FETUA; Fetuin-A; HSGA
Gene Symbols: AHSG
Molecular weight: 39,341 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene