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TRPM1
Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily. Expressed in the retina where it localizes to the outer plexiform layer. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of Human Ortholog: 15q13.3 |
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Cellular Component:
integral component of plasma membrane; new growing cell tip; plasma membrane
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Molecular Function:
calcium channel activity
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Biological Process:
calcium ion transmembrane transport; calcium ion transport into cytosol; cellular response to light stimulus; G protein-coupled glutamate receptor signaling pathway; protein tetramerization; retinal rod cell development; visual perception
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Disease: Night Blindness, Congenital Stationary, Type 1c
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Reference #:
Q7Z4N2
(UniProtKB)
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Alt. Names/Synonyms: CSNB1C; Long transient receptor potential channel 1; LTRPC1; melastatin 1; Melastatin-1; MLSN; MLSN1; Transient receptor potential cation channel subfamily M member 1; transient receptor potential cation channel, subfamily M, member 1; transient receptor potential melastatin family; TRPM1
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Gene Symbols: TRPM1
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Molecular weight:
182,178 Da
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Basal Isoelectric point:
6.4
Predict pI for various phosphorylation states
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