ACSS2 Activates acetate so that it can be used for lipid synthesis or for energy generation. Belongs to the ATP-dependent AMP-binding enzyme family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC; Ligase
Chromosomal Location of mouse Ortholog: 2|2 H1
Cellular Component:  cytoplasm; cytosol
Molecular Function:  acetate-CoA ligase activity; ATP binding; ligase activity; nucleotide binding; propionate-CoA ligase activity
Biological Process:  acetate biosynthetic process; acetyl-CoA biosynthetic process; lipid biosynthetic process; lipid metabolic process; propionate biosynthetic process
Reference #:  Q9QXG4 (UniProtKB)
Alt. Names/Synonyms: 1110017C11Rik; ACAS; Acas1; Acas2; AceC; AceCS; Acecs1; Acetate--CoA ligase; Acetyl-CoA synthetase; acetyl-CoA synthetase 1; acetyl-Coenzyme A synthetase 1 (AMP forming); acetyl-Coenzyme A synthetase 2 (ADP forming); acetyl-Coenzyme A synthetase 2 (AMP forming); Acetyl-coenzyme A synthetase, cytoplasmic; ACS; Acs1; ACSA; Acss2; Acyl-activating enzyme; Acyl-CoA synthetase short-chain family member 2; OTTMUSP00000017177; Propionate--CoA ligase
Gene Symbols: Acss2
Molecular weight: 78,862 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene