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ACSS2
Activates acetate so that it can be used for lipid synthesis or for energy generation. Belongs to the ATP-dependent AMP-binding enzyme family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Ligase |
| Chromosomal Location of human Ortholog: 20q11.22 |
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Cellular Component:
cytoplasm; cytosol; mitochondrial matrix
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Molecular Function:
acetate-CoA ligase activity; AMP binding; ATP binding; propionate-CoA ligase activity
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Biological Process:
acetate biosynthetic process; acetyl-CoA biosynthetic process; acetyl-CoA biosynthetic process from acetate; ethanol oxidation; lipid biosynthetic process; propionate biosynthetic process
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Reference #:
Q9NR19
(UniProtKB)
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Alt. Names/Synonyms: ACAS2; AceCS; AceCS1; acetate thiokinase; Acetate--CoA ligase; acetate-CoA ligase; Acetyl-CoA synthetase; Acetyl-CoA synthetase 1; acetyl-Coenzyme A synthetase 2 (ADP forming); Acetyl-coenzyme A synthetase, cytoplasmic; ACS; ACSA; ACSS2; Acyl-activating enzyme; acyl-CoA synthetase short chain family member 2; Acyl-CoA synthetase short-chain family member 2; cytoplasmic acetyl-coenzyme A synthetase; dJ1161H23.1; DKFZp762G026; Propionate--CoA ligase
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Gene Symbols: ACSS2
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Molecular weight:
78,580 Da
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Basal Isoelectric point:
6.02
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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