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CBX4
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.-; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 17q25.3 |
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Cellular Component:
nuclear body; nuclear speck; nucleoplasm; nucleus; PcG protein complex; PRC1 complex
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Molecular Function:
chromatin binding; enzyme binding; methylated histone binding; phosphoprotein binding; protein binding; single-stranded RNA binding; SUMO binding; SUMO ligase activity; SUMO transferase activity; transcription cis-regulatory region binding; transcription corepressor activity
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Biological Process:
chromatin organization; negative regulation of apoptotic process; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; protein sumoylation
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Reference #:
O00257
(UniProtKB)
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Alt. Names/Synonyms: CBX4; chromobox 4; chromobox homolog 4 (Pc class homolog, Drosophila); Chromobox protein homolog 4; chromobox-like protein 4; E3 SUMO-protein ligase CBX4; hPc2; NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog; Pc2; Polycomb 2 homolog
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Gene Symbols: CBX4
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Molecular weight:
61,368 Da
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Basal Isoelectric point:
9.41
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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