CBX4 E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 17q25.3
Cellular Component:  nuclear body; nuclear speck; nucleoplasm; nucleus; PcG protein complex; PRC1 complex
Molecular Function:  chromatin binding; enzyme binding; methylated histone binding; phosphoprotein binding; protein binding; single-stranded RNA binding; SUMO binding; SUMO ligase activity; SUMO transferase activity; transcription cis-regulatory region binding; transcription corepressor activity
Biological Process:  chromatin organization; negative regulation of apoptotic process; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; protein sumoylation
Reference #:  O00257 (UniProtKB)
Alt. Names/Synonyms: CBX4; chromobox 4; chromobox homolog 4 (Pc class homolog, Drosophila); Chromobox protein homolog 4; chromobox-like protein 4; E3 SUMO-protein ligase CBX4; hPc2; NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog; Pc2; Polycomb 2 homolog
Gene Symbols: CBX4
Molecular weight: 61,368 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein