SPR Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. Belongs to the sepiapterin reductase family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - folate biosynthesis; EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 2p13.2
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  aldo-keto reductase (NADP) activity; NADP binding; sepiapterin reductase activity
Biological Process:  cofactor metabolic process; nitric oxide biosynthetic process; oxidation-reduction process; regulation of nitric-oxide synthase activity; tetrahydrobiopterin biosynthetic process
Disease: Dystonia, Dopa-responsive, Due To Sepiapterin Reductase Deficiency
Reference #:  P35270 (UniProtKB)
Alt. Names/Synonyms: SDR38C1; Sepiapterin reductase; sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase); Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming); short chain dehydrogenase/reductase family 38C, member 1; SPR; SPRE
Gene Symbols: SPR
Molecular weight: 28,048 Da
Basal Isoelectric point: 8.25  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene