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SPR
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. Belongs to the sepiapterin reductase family. Note: This description may include information from UniProtKB.
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| Protein type: Cofactor and Vitamin Metabolism - folate biosynthesis; EC 1.1.1.153; Oxidoreductase |
| Chromosomal Location of human Ortholog: 2p13.2 |
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Cellular Component:
cytosol; nucleoplasm
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Molecular Function:
aldo-keto reductase (NADP) activity; NADP binding; sepiapterin reductase activity
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Biological Process:
nitric oxide biosynthetic process; tetrahydrobiopterin biosynthetic process
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Disease: Dystonia, Dopa-responsive, Due To Sepiapterin Reductase Deficiency
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Reference #:
P35270
(UniProtKB)
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Alt. Names/Synonyms: SDR38C1; Sepiapterin reductase; sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase); Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming); short chain dehydrogenase/reductase family 38C, member 1; SPR; SPRE
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Gene Symbols: SPR
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Molecular weight:
28,048 Da
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Basal Isoelectric point:
8.25
Predict pI for various phosphorylation states
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