CRYZ Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. Only very low amounts in the lens. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.6.5.5; Oxidoreductase; RNA-binding
Chromosomal Location of Human Ortholog: 3|3 H4
Cellular Component:  cytoplasm; cytosol
Molecular Function:  mRNA 3'-UTR binding; NADP binding; NADPH binding; NADPH:quinone reductase activity; oxidoreductase activity; RNA binding; zinc ion binding
Biological Process:  protein homotetramerization; xenobiotic catabolic process
Reference #:  P47199 (UniProtKB)
Alt. Names/Synonyms: crystallin, zeta; Cryz; NADPH:quinone reductase; OTTMUSP00000026037; QOR; Quinone oxidoreductase; quinone reductase; SEZ; Sez9; Zeta-crystallin
Gene Symbols: Cryz
Molecular weight: 35,269 Da
Basal Isoelectric point: 8.18  Predict pI for various phosphorylation states
Select Structure to View Below

CRYZ

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene