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CRYZ
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. Only very low amounts in the lens. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.6.5.5; Oxidoreductase; RNA-binding |
| Chromosomal Location of human Ortholog: 1p31.1 |
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Cellular Component:
cytosol
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Molecular Function:
identical protein binding; mRNA 3'-UTR binding; NADH binding; NADPH binding; NADPH:quinone reductase activity; zinc ion binding
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Biological Process:
protein homotetramerization; visual perception; xenobiotic catabolic process
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Reference #:
Q08257
(UniProtKB)
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Alt. Names/Synonyms: crystallin zeta; crystallin, zeta; crystallin, zeta (quinone reductase); CRYZ; DKFZp779E0834; epididymis secretory sperm binding protein; FLJ41475; NADPH:quinone reductase; QOR; Quinone oxidoreductase; Zeta-crystallin
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Gene Symbols: CRYZ
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Molecular weight:
35,207 Da
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Basal Isoelectric point:
8.56
Predict pI for various phosphorylation states
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