SYN1 Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. Belongs to the synapsin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: Xp11.3-p11.23
Cellular Component:  anchored component of synaptic vesicle membrane; axon; cell junction; cytoskeleton; cytosol; dendrite; extrinsic component of synaptic vesicle membrane; Golgi apparatus; postsynaptic density; presynaptic active zone; Schaffer collateral - CA1 synapse; synaptic vesicle; synaptonemal complex
Molecular Function:  actin binding; ATP binding; calcium-dependent protein binding; protein binding; protein kinase binding
Biological Process:  chemical synaptic transmission; neuron development; regulation of neurotransmitter secretion; regulation of synaptic vesicle exocytosis; synapse organization; synaptic vesicle clustering
Disease: Epilepsy, X-linked, With Variable Learning Disabilities And Behavior Disorders
Reference #:  P17600 (UniProtKB)
Alt. Names/Synonyms: Brain protein 4.1; MRX50; SYN1; SYN1a; SYN1b; Synapsin I; synapsin Ib; Synapsin-1; SYNI
Gene Symbols: SYN1
Molecular weight: 74,111 Da
Basal Isoelectric point: 9.84  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SYN1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein