MCOLN3 one of members of the mucolipin cation channel proteins. Mutation studies of the highly similar protein in mice have shown that the protein is found in cochlea hair cells, and mutant mice show early-onset hearing loss and balance problems. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p22.3
Cellular Component:  autophagosome membrane; early endosome membrane; integral component of membrane; late endosome membrane; plasma membrane
Molecular Function:  lipid binding
Biological Process:  calcium ion transmembrane transport; inner ear auditory receptor cell differentiation; locomotory behavior; release of sequestered calcium ion into cytosol
Reference #:  Q8TDD5 (UniProtKB)
Alt. Names/Synonyms: FLJ11006; FLJ36629; MCLN3; MCOLN3; MGC71509; mucolipin 3; Mucolipin-3; TRP-ML3; TRPML3
Gene Symbols: MCOLN3
Molecular weight: 64,248 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene