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ACAA2
In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation. Abolishes BNIP3-mediated apoptosis and mitochondrial damage. Belongs to the thiolase-like superfamily. Thiolase family. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 2.3.1.16; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Transferase |
| Chromosomal Location of mouse Ortholog: 18 E2|18 50.76 cM |
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Cellular Component:
mitochondrial matrix; mitochondrion
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Molecular Function:
acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity; acetyl-CoA hydrolase activity; acyl-CoA hydrolase activity; acyltransferase activity; acyltransferase activity, transferring groups other than amino-acyl groups; hydrolase activity; myristoyl-CoA hydrolase activity; palmitoyl-CoA hydrolase activity; transferase activity
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Biological Process:
acetyl-CoA metabolic process; cellular response to hypoxia; fatty acid beta-oxidation; fatty acid metabolic process; lipid metabolic process; negative regulation of mitochondrial membrane permeability involved in apoptotic process; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
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Reference #:
Q8BWT1
(UniProtKB)
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Alt. Names/Synonyms: 0610011L04Rik; 3-ketoacyl-CoA thiolase, mitochondrial; Acaa2; Acetyl-CoA acetyltransferase; Acetyl-CoA acyltransferase; acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase); Acyl-CoA hydrolase, mitochondrial; AI255831; AI265397; Beta-ketothiolase; D18Ertd240; D18Ertd240e; Mitochondrial 3-oxoacyl-CoA thiolase; THIM
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Gene Symbols: Acaa2
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Molecular weight:
41,830 Da
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Basal Isoelectric point:
8.33
Predict pI for various phosphorylation states
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