ACAA2 Abolishes BNIP3-mediated apoptosis and mitochondrial damage. Belongs to the thiolase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Transferase
Chromosomal Location of Human Ortholog: 18 E2|18 50.76 cM
Cellular Component:  mitochondrial matrix; mitochondrion
Molecular Function:  acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity; catalytic activity; transferase activity; transferase activity, transferring acyl groups; transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process:  acetyl-CoA metabolic process; cellular response to hypoxia; fatty acid beta-oxidation; fatty acid metabolic process; lipid metabolic process; negative regulation of mitochondrial membrane permeability involved in apoptotic process; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Reference #:  Q8BWT1 (UniProtKB)
Alt. Names/Synonyms: 0610011L04Rik; 3-ketoacyl-CoA thiolase, mitochondrial; Acaa2; Acetyl-CoA acyltransferase; acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase); AI255831; AI265397; Beta-ketothiolase; D18Ertd240e; Mitochondrial 3-oxoacyl-CoA thiolase; THIM
Gene Symbols: Acaa2
Molecular weight: 41,830 Da
Basal Isoelectric point: 8.33  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene