|
SDHA
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.3.5.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase; Tumor suppressor |
| Chromosomal Location of Human Ortholog: 5p15.33 |
|
Cellular Component:
mitochondrial inner membrane; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone); mitochondrion; nucleolus
|
|
Molecular Function:
protein binding; succinate dehydrogenase (ubiquinone) activity
|
|
Biological Process:
nervous system development; oxidation-reduction process; respiratory electron transport chain; succinate metabolic process; tricarboxylic acid cycle
|
|
Disease: Cardiomyopathy, Dilated, 1gg; Leigh Syndrome; Mitochondrial Complex Ii Deficiency; Paragangliomas 5
|
|
Reference #:
P31040
(UniProtKB)
|
|
Alt. Names/Synonyms: CMD1GG; DHSA; Flavoprotein subunit of complex II; Fp; FpSDH; PGL5; SDH1; SDH2; SDHA; SDHF; Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; succinate dehydrogenase complex flavoprotein subunit; succinate dehydrogenase complex flavoprotein subunit A; succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
|
|
Gene Symbols: SDHA
|
|
Molecular weight:
72,692 Da
|
|
Basal Isoelectric point:
7.06
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
