HADHSC Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA. Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. Expressed in liver, kidney, pancreas, heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC 1.1.1.35; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Oxidoreductase
Chromosomal Location of Human Ortholog: 4q25
Cellular Component:  cytoplasm; mitochondrial matrix; mitochondrion; nucleoplasm
Molecular Function:  3-hydroxyacyl-CoA dehydrogenase activity; NAD+ binding
Biological Process:  fatty acid beta-oxidation; negative regulation of insulin secretion; positive regulation of cold-induced thermogenesis; response to activity; response to drug; response to insulin
Disease: 3-hydroxyacyl-coa Dehydrogenase Deficiency; Hyperinsulinemic Hypoglycemia, Familial, 4
Reference #:  Q16836 (UniProtKB)
Alt. Names/Synonyms: HAD; HADH; HADH1; HADHSC; HCDH; HHF4; hydroxyacyl-Coenzyme A dehydrogenase; Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain; M/SCHAD; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; MGC8392; SCHAD; Short-chain 3-hydroxyacyl-CoA dehydrogenase
Gene Symbols: HADH
Molecular weight: 34,294 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
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HADHSC

Protein Structure Not Found.


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