MRPL47 a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene is immediately adjacent to the gene for BAF complex 53 kDa subunit protein a (BAF53a), in a tail-to-tail orientation. Two transcript variants encoding different protein isoforms have been identified. [provided by RefSeq, Jul 2008]
Protein type: Mitochondrial; Ribosomal; Translation
Chromosomal Location of Human Ortholog: 3q26.33
Cellular Component:  mitochondrial inner membrane; mitochondrial large ribosomal subunit; mitochondrion
Molecular Function:  protein binding
Biological Process:  mitochondrial translational elongation; mitochondrial translational termination
Reference #:  Q9HD33 (UniProtKB)
Alt. Names/Synonyms: 39S ribosomal protein L47, mitochondrial; CGI-204; L47mt; MGC45403; mitochondrial ribosomal protein L47; MRP-L47; MRPL47; nasopharyngeal carcinoma metastasis-related 1; Nasopharyngeal carcinoma metastasis-related protein 1; NCM1; RM47
Gene Symbols: MRPL47
Molecular weight: 29,450 Da
Basal Isoelectric point: 10.38  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein