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STF-1
Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Belongs to the nuclear hormone receptor family. NR5 subfamily. High expressed in the adrenal cortex, the ovary, the testis, and the spleen (PubMed:9177385). Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 9q33.3 |
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Cellular Component:
chromatin; cytosol; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex
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Molecular Function:
chromatin binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; nuclear receptor activity; phospholipid binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription coregulator binding; zinc ion binding
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Biological Process:
adrenal gland development; calcineurin-mediated signaling; female gonad development; hormone metabolic process; hormone-mediated signaling pathway; intracellular receptor signaling pathway; Leydig cell differentiation; luteinization; maintenance of protein location in nucleus; male gonad development; male sex determination; negative regulation of female gonad development; positive regulation of gene expression; positive regulation of male gonad development; positive regulation of transcription by RNA polymerase II; primary sex determination; regulation of steroid biosynthetic process; regulation of transcription by RNA polymerase II; response to gonadotropin-releasing hormone; Sertoli cell differentiation; sex determination; tissue development; transcription by RNA polymerase II
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Disease: 46,xx Sex Reversal 4; 46,xy Sex Reversal 3; Premature Ovarian Failure 7; Spermatogenic Failure 8
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Reference #:
Q13285
(UniProtKB)
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Alt. Names/Synonyms: AD4BP; adrenal 4 binding protein; Adrenal 4-binding protein; ELP; FTZ1; FTZF1; Fushi tarazu factor homolog 1; hSF-1; NR5A1; nuclear receptor AdBP4; Nuclear receptor subfamily 5 group A member 1; nuclear receptor subfamily 5, group A, member 1; POF7; SF-1; SF1; SPGF8; SRXX4; SRXY3; Steroid hormone receptor Ad4BP; Steroidogenic factor 1; steroidogenic factor 1 nuclear receptor; steroidogenic factor-1; STF-1; STF1
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Gene Symbols: NR5A1
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Molecular weight:
51,636 Da
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Basal Isoelectric point:
7.81
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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