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ACSS1
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions. Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2). Belongs to the ATP-dependent AMP-binding enzyme family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Ligase; Mitochondrial |
| Chromosomal Location of mouse Ortholog: 2|2 G3 |
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Cellular Component:
mitochondrial matrix; mitochondrion
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Molecular Function:
acetate-CoA ligase activity; AMP binding; ATP binding; ligase activity; nucleotide binding; propionate-CoA ligase activity
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Biological Process:
acetate biosynthetic process; acetyl-CoA biosynthetic process; acetyl-CoA biosynthetic process from acetate; lipid metabolic process; propionate biosynthetic process
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Reference #:
Q99NB1
(UniProtKB)
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Alt. Names/Synonyms: 1110032O15Rik; Acas2; Acas2l; AceC; AceCS2; Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; acetyl-CoA synthetase 2-like; acetyl-Coenzyme A synthetase 2 (AMP forming)-like; Acetyl-coenzyme A synthetase 2-like, mitochondrial; ACS2L; Acss1; Acyl-CoA synthetase short-chain family member 1; AI788978; OTTMUSP00000016746; Propionate--CoA ligase
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Gene Symbols: Acss1
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Molecular weight:
74,623 Da
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Basal Isoelectric point:
6.51
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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