ACSS1 Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions. Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2). Belongs to the ATP-dependent AMP-binding enzyme family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC; Ligase; Mitochondrial
Chromosomal Location of human Ortholog: 20p11.21
Cellular Component:  mitochondrial matrix; mitochondrion
Molecular Function:  acetate-CoA ligase activity; AMP binding; ATP binding; propionate-CoA ligase activity; protein binding
Biological Process:  acetate biosynthetic process; acetyl-CoA biosynthetic process; acetyl-CoA biosynthetic process from acetate; ethanol oxidation; propionate biosynthetic process
Reference #:  Q9NUB1 (UniProtKB)
Alt. Names/Synonyms: ACAS2L; ACECS1; AceCS2; AceCS2L; Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; acetyl-Coenzyme A synthetase 2 (AMP forming)-like; Acetyl-coenzyme A synthetase 2-like, mitochondrial; ACS2L; ACSS1; acyl-CoA synthetase short chain family member 1; Acyl-CoA synthetase short-chain family member 1; FLJ45659; KIAA1846; MGC33843; Propionate--CoA ligase
Gene Symbols: ACSS1
Molecular weight: 74,857 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein