RASA2 Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras
Chromosomal Location of Human Ortholog: 3q23
Cellular Component:  cytosol; perinuclear region of cytoplasm
Molecular Function:  GTPase activator activity; metal ion binding; phospholipid binding
Biological Process:  MAPK cascade; negative regulation of Ras protein signal transduction; positive regulation of GTPase activity; signal transduction
Reference #:  Q15283 (UniProtKB)
Alt. Names/Synonyms: GAP1M; GTPase-activating protein of RAS; Ras GTPase-activating protein 2; RAS p21 protein activator 2; RASA2; RASGAP
Gene Symbols: RASA2
Molecular weight: 96,614 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  T Cell Receptor Signaling
Select Structure to View Below

RASA2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene