SEC63 Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia. Widely expressed, with high levels in the liver. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6q21
Cellular Component:  cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; membrane
Molecular Function:  protein binding; signaling receptor activity
Biological Process:  liver development; multicellular organism aging; nitrogen compound metabolic process; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation; protein targeting to membrane; SRP-dependent cotranslational protein targeting to membrane
Disease: Polycystic Liver Disease 2
Reference #:  Q9UGP8 (UniProtKB)
Alt. Names/Synonyms: DNAJC23; ERdj2; PCLD2; PRO2507; SEC63; SEC63 homolog (S. cerevisiae); SEC63 homolog, protein translocation regulator; SEC63 protein translocation regulator; SEC63-like; SEC63-like protein; SEC63L; Translocation protein SEC63 homolog
Gene Symbols: SEC63
Molecular weight: 87,997 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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