CLIC1 Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Belongs to the chloride channel CLIC family. Expression is prominent in heart, placenta, liver, kidney and pancreas. Note: This description may include information from UniProtKB.
Protein type: Channel, chloride; Membrane protein, integral; Nuclear envelope
Chromosomal Location of mouse Ortholog: 17 B1|17 18.58 cM
Cellular Component:  chloride channel complex; cytoplasm; extracellular exosome; membrane; mitochondrion; nuclear envelope; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  chloride channel activity; voltage-gated monoatomic ion channel activity
Biological Process:  chloride transport; monoatomic ion transport; positive regulation of osteoblast differentiation; regulation of mitochondrial membrane potential; regulation of monoatomic ion transmembrane transport
Reference #:  Q9Z1Q5 (UniProtKB)
Alt. Names/Synonyms: chloride intracellular channel 1; Chloride intracellular channel protein 1; Clcp; Clic1; G6; NCC27; Nuclear chloride ion channel 27
Gene Symbols: Clic1
Molecular weight: 27,013 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein