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CLIC1
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Belongs to the chloride channel CLIC family. Expression is prominent in heart, placenta, liver, kidney and pancreas. Note: This description may include information from UniProtKB.
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| Protein type: Channel, chloride; Membrane protein, integral; Nuclear envelope |
| Chromosomal Location of human Ortholog: 6p21.33 |
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Cellular Component:
brush border; chloride channel complex; cytoplasm; endoplasmic reticulum; extracellular exosome; membrane; mitochondrion; nuclear envelope; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane
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Molecular Function:
chloride channel activity; protein binding; voltage-gated monoatomic ion channel activity
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Biological Process:
chloride transmembrane transport; chloride transport; positive regulation of osteoblast differentiation; regulation of mitochondrial membrane potential; regulation of monoatomic ion transmembrane transport; signal transduction
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Reference #:
O00299
(UniProtKB)
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Alt. Names/Synonyms: Chloride channel ABP; chloride intracellular channel 1; Chloride intracellular channel protein 1; CL1C1; CLCNL1; CLIC1; G6; hRNCC; NCC27; Nuclear chloride ion channel 27; nuclear chloride ion channel protein; p64CLCP; Regulatory nuclear chloride ion channel protein; RNCC protein
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Gene Symbols: CLIC1
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Molecular weight:
26,923 Da
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Basal Isoelectric point:
5.09
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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