MCU Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. participates in mitochondrial permeability transition during ischemia-reperfusion injury. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation. Belongs to the MCU (TC 1.A.77) family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial
Chromosomal Location of Human Ortholog: 10q22.1
Cellular Component:  calcium channel complex; integral component of mitochondrial inner membrane; mitochondrial inner membrane; mitochondrion; uniplex complex
Molecular Function:  calcium channel activity; identical protein binding; protein binding; uniporter activity
Biological Process:  calcium import into the mitochondrion; calcium-mediated signaling; glucose homeostasis; mitochondrial calcium ion transmembrane transport; positive regulation of insulin secretion; positive regulation of mitochondrial calcium ion concentration; protein complex oligomerization
Reference #:  Q8NE86 (UniProtKB)
Alt. Names/Synonyms: C109A; C10orf42; Calcium uniporter protein, mitochondrial; CCDC109A; coiled-coil domain containing 109A; Coiled-coil domain-containing protein 109A; FLJ46135; HsMCU; MCU; mitochondrial calcium uniporter
Gene Symbols: MCU
Molecular weight: 39,867 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene