ANKRD11 Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells. May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Has a role in proliferation and development of cortical neural precursors. May also regulate bone homeostasis. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component:  cytosol; nucleoplasm; nucleus; plasma membrane
Biological Process:  bone development; face morphogenesis; in utero embryonic development; multicellular organism growth; odontogenesis of dentin-containing tooth; skeletal system morphogenesis; tissue homeostasis
Disease: Kbg Syndrome
Reference #:  Q6UB99 (UniProtKB)
Alt. Names/Synonyms: ANCO-1; ANCO1; ANKRD11; ankyrin repeat domain 11; Ankyrin repeat domain-containing protein 11; Ankyrin repeat-containing cofactor 1; ankyrin repeat-containing protein 11; ANR11; LZ16; nasopharyngeal carcinoma susceptibility protein; T13; truncated ankyrin repeat domain 11 aberrant transcript 1; truncated ankyrin repeat domain 11 aberrant transcript 2
Gene Symbols: ANKRD11
Molecular weight: 297,913 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA