STAT6 Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. Belongs to the transcription factor STAT family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component:  cytosol; membrane raft; nuclear chromatin; nuclear membrane; nucleoplasm
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein phosphatase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; cytokine-mediated signaling pathway; interleukin-4-mediated signaling pathway; mammary gland epithelial cell proliferation; mammary gland morphogenesis; negative regulation of transcription by RNA polymerase II; negative regulation of type 2 immune response; positive regulation of cold-induced thermogenesis; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription by RNA polymerase II; positive regulation of type I interferon production; regulation of cell proliferation; regulation of transcription by RNA polymerase II; signal transduction; T-helper 1 cell lineage commitment
Reference #:  P42226 (UniProtKB)
Alt. Names/Synonyms: D12S1644; IL-4 Stat; IL-4-STAT; Signal transducer and activator of transcription 6; signal transducer and activator of transcription 6, interleukin-4 induced; STAT, interleukin4-induced; STAT6; STAT6B; STAT6C; transcription factor IL-4 STAT
Gene Symbols: STAT6
Molecular weight: 94,135 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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