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STAT6
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. Belongs to the transcription factor STAT family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 12q13.3 |
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Cellular Component:
chromatin; cytosol; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex
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Molecular Function:
DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein phosphatase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription coactivator binding
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Biological Process:
cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; cytokine-mediated signaling pathway; defense response; growth hormone receptor signaling pathway via JAK-STAT; interleukin-4-mediated signaling pathway; isotype switching to IgE isotypes; mammary gland epithelial cell proliferation; mammary gland morphogenesis; negative regulation of transcription by RNA polymerase II; negative regulation of type 2 immune response; positive regulation of cold-induced thermogenesis; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription by RNA polymerase II; receptor signaling pathway via JAK-STAT; regulation of cell population proliferation; regulation of mast cell proliferation; regulation of transcription by RNA polymerase II; response to peptide hormone; signal transduction; T-helper 1 cell lineage commitment
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Disease: Hyper-ige Syndrome 6, Autosomal Dominant, With Recurrent Infections
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Reference #:
P42226
(UniProtKB)
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Alt. Names/Synonyms: D12S1644; IL-4 Stat; IL-4-STAT; Signal transducer and activator of transcription 6; signal transducer and activator of transcription 6, interleukin-4 induced; STAT, interleukin4-induced; STAT6; STAT6B; STAT6C; transcription factor IL-4 STAT
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Gene Symbols: STAT6
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Molecular weight:
94,135 Da
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Basal Isoelectric point:
5.84
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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