IBTK Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 6q14.1
Cellular Component:  cytoplasm; membrane; nucleoplasm
Molecular Function:  protein kinase binding; protein tyrosine kinase inhibitor activity
Biological Process:  negative regulation of protein phosphorylation; negative regulation of protein tyrosine kinase activity; release of sequestered calcium ion into cytosol
Reference #:  Q9P2D0 (UniProtKB)
Alt. Names/Synonyms: Bruton agammaglobulinemia tyrosine kinase inhibitor; BTK-binding protein; BTKI; IBTK; inhibitor of Bruton agammaglobulinemia tyrosine kinase; Inhibitor of Bruton tyrosine kinase; inhibitor of Bruton's tyrosine kinase; inhibitor of Bruton's tyrosine kinase-alpha; inhibitor of Bruton's tyrosine kinase-beta; inhibitor of Bruton's tyrosine kinase-gamma; KIAA1417; MGC142256; MGC142258; RP1-93K22.1
Gene Symbols: IBTK
Molecular weight: 150,528 Da
Basal Isoelectric point: 7.79  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene