ICF45 Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Belongs to the tRNA(His) guanylyltransferase family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 2.7.7.79; Mitochondrial; Transferase
Chromosomal Location of Human Ortholog: 11|11 B1.1
Cellular Component:  cytoplasm; mitochondrion
Molecular Function:  ATP binding; GTP binding; identical protein binding; magnesium ion binding; metal ion binding; nucleotide binding; nucleotidyltransferase activity; transferase activity; tRNA guanylyltransferase activity
Biological Process:  protein homotetramerization; tRNA modification; tRNA processing
Reference #:  Q9CY52 (UniProtKB)
Alt. Names/Synonyms: 1700121M19Rik; 5730409G07Rik; AA387658; MGC107321; nterphase cyctoplasmic foci protein 45; OTTMUSP00000005630; Probable tRNA(His) guanylyltransferase; THG1; Thg1l; tRNA-histidine guanylyltransferase; tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
Gene Symbols: Thg1l
Molecular weight: 34,971 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
Select Structure to View Below

ICF45

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene