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MELL1
Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond. Belongs to the peptidase M13 family. Predominantly expressed in testis. Weakly expressed in brain, kidney and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.24.11; Membrane protein, integral; Protease |
| Chromosomal Location of Human Ortholog: 1p36.32 |
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Cellular Component:
extracellular space; integral component of membrane; membrane
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Molecular Function:
endopeptidase activity; metal ion binding; metalloendopeptidase activity
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Biological Process:
proteolysis
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Reference #:
Q495T6
(UniProtKB)
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Alt. Names/Synonyms: MELL1; Membrane metallo-endopeptidase-like 1; Membrane metallo-endopeptidase-like 1, soluble form; Membrane metallo-endopeptidase-like 2; membrane metalloendopeptidase like 1; MGC119454; MGC119455; MGC119456; MMEL1; MMEL2; NEP2; NEP2(m); NEP2(s); NEPII; Neprilysin II; Neprilysin-2; Neprilysin-2 secreted; NL1; NL2; SEP; soluble secreted endopeptidase; zinc metallopeptidase
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Gene Symbols: MMEL1
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Molecular weight:
89,367 Da
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Basal Isoelectric point:
5.64
Predict pI for various phosphorylation states
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