MELL1 Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond. Belongs to the peptidase M13 family. Predominantly expressed in testis. Weakly expressed in brain, kidney and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Protease
Chromosomal Location of human Ortholog: 1p36.32
Cellular Component:  extracellular space; integral component of membrane; membrane
Molecular Function:  endopeptidase activity; metal ion binding; metalloendopeptidase activity
Biological Process:  proteolysis
Reference #:  Q495T6 (UniProtKB)
Alt. Names/Synonyms: MELL1; Membrane metallo-endopeptidase-like 1; Membrane metallo-endopeptidase-like 1, soluble form; Membrane metallo-endopeptidase-like 2; membrane metalloendopeptidase like 1; MGC119454; MGC119455; MGC119456; MMEL1; MMEL2; NEP2; NEP2(m); NEP2(s); NEPII; Neprilysin II; Neprilysin-2; Neprilysin-2 secreted; NL1; NL2; SEP; soluble secreted endopeptidase; zinc metallopeptidase
Gene Symbols: MMEL1
Molecular weight: 89,367 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene