|
OBFC2B
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-B family. SOSS-B1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cell cycle regulation; DNA repair, damage |
| Chromosomal Location of mouse Ortholog: 10|10 D3 |
|
Cellular Component:
chromosome, telomeric region; cytosol; nucleoplasm; nucleus; site of double-strand break; SOSS complex
|
|
Molecular Function:
DNA binding; DNA polymerase binding; G-rich strand telomeric DNA binding; nucleic acid binding; single-stranded DNA binding
|
|
Biological Process:
DNA damage response; DNA repair; double-strand break repair via homologous recombination; establishment of protein localization to telomere; mitotic cell cycle checkpoint signaling; mitotic G2/M transition checkpoint; positive regulation of telomere capping; response to ionizing radiation
|
|
Reference #:
Q8R2Y9
(UniProtKB)
|
|
Alt. Names/Synonyms: 2610036N15Rik; MGC30353; Nabp2; nucleic acid binding protein 2; Nucleic acid-binding protein 2; Obfc2; Obfc2b; oligonucleotide/oligosaccharide-binding fold containing 2B; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; Single-stranded DNA-binding protein 1; SOSB1; SOSS complex subunit B1; SOSS-B1; Ssb1
|
|
Gene Symbols: Nabp2
|
|
Molecular weight:
22,628 Da
|
|
Basal Isoelectric point:
9.17
Predict pI for various phosphorylation states
|
