OBFC2B Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-B family. SOSS-B1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; DNA repair, damage
Chromosomal Location of human Ortholog: 12q13.3
Cellular Component:  chromosome, telomeric region; cytosol; nucleoplasm; nucleus; site of double-strand break; SOSS complex
Molecular Function:  C-rich strand telomeric DNA binding; DNA binding; DNA polymerase binding; G-rich strand telomeric DNA binding; protein binding; single-stranded DNA binding
Biological Process:  cellular response to DNA damage stimulus; DNA repair; double-strand break repair via homologous recombination; establishment of protein localization to telomere; mitotic cell cycle checkpoint signaling; mitotic G2/M transition checkpoint; positive regulation of telomere capping; regulation of telomerase activity; response to ionizing radiation
Reference #:  Q9BQ15 (UniProtKB)
Alt. Names/Synonyms: hSSB1; LP3587; MGC2731; NABP2; nucleic acid binding protein 2; Nucleic acid-binding protein 2; OBFC2B; oligonucleotide/oligosaccharide-binding fold containing 2B; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; single strand DNA-binding protein 1; Single-stranded DNA-binding protein 1; SOSB1; SOSS complex subunit B1; SOSS-B1; SSB1
Gene Symbols: NABP2
Molecular weight: 22,338 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene