OBFC2B Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Component of the SOSS complex, composed of SOSS-B (SOSS- B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. SOSS complexes containing SOSS-B1/OBFC2B are more abundant than complexes containing SOSS-B2/OBFC2A. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7. Belongs to the SOSS-B family. SOSS-B1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; DNA repair, damage
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component:  cytosol; nuclear chromosome, telomeric region; nucleoplasm; nucleus
Molecular Function:  C-rich strand telomeric DNA binding; G-rich strand telomeric DNA binding; protein binding; single-stranded DNA binding
Biological Process:  cellular response to DNA damage stimulus; DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; positive regulation of telomere capping; regulation of telomerase activity; response to ionizing radiation; snRNA transcription from RNA polymerase II promoter
Reference #:  Q9BQ15 (UniProtKB)
Alt. Names/Synonyms: hSSB1; LP3587; MGC2731; OBFC2B; oligonucleotide/oligosaccharide-binding fold containing 2B; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; Single-stranded DNA-binding protein 1; SOSB1; SOSS complex subunit B1; SOSS-B1; SSB1
Gene Symbols: NABP2
Molecular weight: 22,338 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
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OBFC2B

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene