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OBFC2B
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Component of the SOSS complex, composed of SOSS-B (SOSS- B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. SOSS complexes containing SOSS-B1/OBFC2B are more abundant than complexes containing SOSS-B2/OBFC2A. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7. Belongs to the SOSS-B family. SOSS-B1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; DNA repair, damage |
| Chromosomal Location of Human Ortholog: 12q13.3 |
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Cellular Component:
cytosol; nuclear chromosome, telomeric region; nucleoplasm; nucleus
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Molecular Function:
C-rich strand telomeric DNA binding; G-rich strand telomeric DNA binding; protein binding; single-stranded DNA binding
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Biological Process:
cellular response to DNA damage stimulus; DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; positive regulation of telomere capping; regulation of telomerase activity; response to ionizing radiation; snRNA transcription from RNA polymerase II promoter
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Reference #:
Q9BQ15
(UniProtKB)
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Alt. Names/Synonyms: hSSB1; LP3587; MGC2731; OBFC2B; oligonucleotide/oligosaccharide-binding fold containing 2B; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; Single-stranded DNA-binding protein 1; SOSB1; SOSS complex subunit B1; SOSS-B1; SSB1
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Gene Symbols: NABP2
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Molecular weight:
22,338 Da
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Basal Isoelectric point:
9.17
Predict pI for various phosphorylation states
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