STAT5A transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 fusion protein is essential for the tumorigenesis. Induces the expression of BCL2L1/BCL-X(L) in the mouse, suggesting an antiapoptotic function of this protein. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding
Biological Process:  cytokine-mediated signaling pathway; interleukin-15-mediated signaling pathway; interleukin-2-mediated signaling pathway; interleukin-7-mediated signaling pathway; interleukin-9-mediated signaling pathway; JAK-STAT cascade; JAK-STAT cascade involved in growth hormone signaling pathway; lactation; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell proliferation; reelin-mediated signaling pathway; regulation of multicellular organism growth; regulation of transcription by RNA polymerase II; taurine metabolic process
Reference #:  P42229 (UniProtKB)
Alt. Names/Synonyms: MGF; Signal transducer and activator of transcription 5A; STA5A; STAT5; STAT5A
Gene Symbols: STAT5A
Molecular weight: 90,647 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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STAT5A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene