DHX36 a multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (helical structures containing guanine tetrads). Plays a role in deadenylation and degradation of mRNAs containing in their 3'-UTR consensus AU-rich elements (AREs). Plays a role in many biological processes such as genomic integrity, transcriptional regulation, and as a sensor to initiate antiviral responses. Plays a role in post-transcriptional regulation. For example, it unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage. Converts the G4-RNA structure present in telomerase RNA template component (TREC) into double-stranded RNA that acts as a template boundary ensuring accurate reverse transcription. Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment, where it is involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size. Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1. Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification. Belongs to the DEAD box helicase family. DEAH subfamily. Highly expressed in testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Helicase; RNA-binding
Chromosomal Location of mouse Ortholog: 3|3 E1
Cellular Component:  axon; cell projection; chromosome; chromosome, telomeric region; cytoplasm; cytoplasmic stress granule; cytosol; dendrite; intracellular anatomical structure; mitochondrion; nuclear speck; nucleoplasm; nucleus; perikaryon
Molecular Function:  ATP binding; ATP-dependent activity, acting on DNA; DNA binding; DNA helicase activity; double-stranded RNA binding; G-quadruplex DNA binding; G-quadruplex RNA binding; helicase activity; histone deacetylase binding; hydrolase activity; magnesium ion binding; metal ion binding; mRNA 3'-UTR AU-rich region binding; mRNA 3'-UTR binding; mRNA 5'-UTR binding; nucleic acid binding; nucleotide binding; pre-miRNA binding; protein binding; RNA binding; RNA helicase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; single-stranded DNA binding; telomerase RNA binding; transcription cis-regulatory region binding
Biological Process:  3'-UTR-mediated mRNA destabilization; cell differentiation; cellular response to arsenite ion; cellular response to heat; cellular response to UV; defense response to virus; G-quadruplex DNA unwinding; immune system process; innate immune response; multicellular organism development; negative regulation of translation; ossification; positive regulation of cardioblast differentiation; positive regulation of cytoplasmic translation; positive regulation of dendritic spine morphogenesis; positive regulation of gene expression; positive regulation of hematopoietic progenitor cell differentiation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-alpha production; positive regulation of intracellular mRNA localization; positive regulation of mRNA 3'-end processing; positive regulation of myeloid dendritic cell cytokine production; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of telomere maintenance; positive regulation of telomere maintenance via telomere lengthening; positive regulation of transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; regulation of embryonic development; regulation of mRNA stability; regulation of transcription by RNA polymerase III; regulation of translation; response to exogenous dsRNA; response to virus; RNA secondary structure unwinding; spermatogenesis; telomerase RNA stabilization
Reference #:  Q8VHK9 (UniProtKB)
Alt. Names/Synonyms: 2810407E23Rik; AI452301; ATP-dependent DNA/RNA helicase DHX36; ATP-dependent RNA helicase DHX36; AU022184; Ddx36; DEAD/H box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH box protein 36; Dhx36; Kiaa1488; mKIAA1488; MLE-like protein 1; Mlel1; OTTMUSP00000031786; Probable ATP-dependent RNA helicase DHX36; RNA helicase associated with AU-rich element ARE
Gene Symbols: Dhx36
Molecular weight: 113,883 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein