DHX36 Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. Belongs to the DEAD box helicase family. DEAH subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding
Chromosomal Location of Human Ortholog: 3q25.2
Cellular Component:  chromosome, telomeric region; cytoplasm; cytosol; intracellular; nucleus
Molecular Function:  ATP binding; ATP-dependent DNA helicase activity; DNA-dependent ATPase activity; double-stranded RNA binding; G-quadruplex DNA binding; histone deacetylase binding; protein binding; single-stranded DNA binding; telomerase RNA binding; transcription regulatory region DNA binding
Biological Process:  ossification; positive regulation of interferon type I production; positive regulation of interferon-alpha secretion; positive regulation of telomere maintenance; positive regulation of transcription from RNA polymerase II promoter; response to exogenous dsRNA; response to virus; RNA secondary structure unwinding; transcription, DNA-dependent
Reference #:  Q9H2U1 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase DHX36; DDX36; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH box protein 36; DHX36; G4 resolvase-1; G4R1; KIAA1488; MLE-like protein 1; MLEL1; Probable ATP-dependent RNA helicase DHX36; RHAU; RNA helicase associated with AU-rich element ARE
Gene Symbols: DHX36
Molecular weight: 114,760 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
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DHX36

Protein Structure Not Found.


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