DHX36 Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. Belongs to the DEAD box helicase family. DEAH subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Helicase; RNA-binding
Chromosomal Location of Human Ortholog: 3q25.2
Cellular Component:  axon; chromosome, telomeric region; cytoplasm; cytoplasmic stress granule; cytosol; dendrite; mitochondrion; nuclear speck; nucleus; perikaryon
Molecular Function:  ATP binding; ATP-dependent DNA helicase activity; ATP-dependent RNA helicase activity; DNA-dependent ATPase activity; double-stranded RNA binding; G-quadruplex DNA binding; G-quadruplex RNA binding; histone deacetylase binding; magnesium ion binding; mRNA 3'-UTR AU-rich region binding; mRNA 3'-UTR binding; mRNA 5'-UTR binding; pre-miRNA binding; protein binding; RNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; single-stranded DNA binding; telomerase RNA binding; transcription regulatory region DNA binding
Biological Process:  3'-UTR-mediated mRNA destabilization; cellular response to arsenite ion; cellular response to heat; cellular response to UV; defense response to virus; DNA duplex unwinding; G-quadruplex DNA unwinding; innate immune response; negative regulation of translation; ossification; positive regulation of cardioblast differentiation; positive regulation of cytoplasmic translation; positive regulation of dendritic spine morphogenesis; positive regulation of gene expression; positive regulation of hematopoietic progenitor cell differentiation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-alpha secretion; positive regulation of intracellular mRNA localization; positive regulation of mRNA 3'-end processing; positive regulation of myeloid dendritic cell cytokine production; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of telomere maintenance; positive regulation of telomere maintenance via telomere lengthening; positive regulation of transcription by RNA polymerase II; positive regulation of transcription initiation from RNA polymerase II promoter; positive regulation of type I interferon production; regulation of embryonic development; regulation of mRNA stability; regulation of transcription by RNA polymerase III; regulation of transcription from RNA polymerase II promoter involved in spermatogenesis; response to exogenous dsRNA; RNA secondary structure unwinding; spermatogenesis; telomerase RNA stabilization
Reference #:  Q9H2U1 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase DHX36; DDX36; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH box protein 36; DHX36; G4 resolvase-1; G4R1; KIAA1488; MLE-like protein 1; MLEL1; Probable ATP-dependent RNA helicase DHX36; RHAU; RNA helicase associated with AU-rich element ARE
Gene Symbols: DHX36
Molecular weight: 114,760 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein