SPOPL Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP. Belongs to the Tdpoz family. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 2|2 A3
Cellular Component:  Cul3-RING ubiquitin ligase complex; cytoplasm; nucleus
Molecular Function:  ubiquitin protein ligase binding
Biological Process:  negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of proteolysis
Reference #:  Q2M2N2 (UniProtKB)
Alt. Names/Synonyms: 4921517N04Rik; AU014935; BB233739; E430033K04Rik; HIB homolog 2; MGC130583; OTTMUSP00000012241; RIKEN cDNA 4921517N04; speckle-type BTB/POZ protein-like; Speckle-type POZ protein-like; Spopl
Gene Symbols: Spopl
Molecular weight: 44,699 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein