SPOPL
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP. Belongs to the Tdpoz family. Note: This description may include information from UniProtKB.
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Protein type: Transcription, coactivator/corepressor |
Chromosomal Location of human Ortholog: 2q22.1 |
Cellular Component:
Cul3-RING ubiquitin ligase complex; cytoplasm; nucleus
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Molecular Function:
protein binding; ubiquitin protein ligase binding
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Biological Process:
negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; regulation of proteolysis
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Reference #:
Q6IQ16
(UniProtKB)
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Alt. Names/Synonyms: BTBD33; FLJ53775; HIB homolog 2; Roadkill homolog 2; speckle type BTB/POZ protein like; Speckle-type POZ protein-like; SPOPL
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Gene Symbols: SPOPL
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Molecular weight:
44,647 Da
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Basal Isoelectric point:
6.99
Predict pI for various phosphorylation states
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