STAT4 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q32.2-q32.3
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding
Biological Process:  cytokine-mediated signaling pathway; interleukin-12-mediated signaling pathway; interleukin-21-mediated signaling pathway; interleukin-23-mediated signaling pathway; interleukin-35-mediated signaling pathway; JAK-STAT cascade; positive regulation of transcription by RNA polymerase II
Disease: Systemic Lupus Erythematosus, Susceptibility To, 11
Reference #:  Q14765 (UniProtKB)
Alt. Names/Synonyms: Signal transducer and activator of transcription 4; SLEB11; STAT4
Gene Symbols: STAT4
Molecular weight: 85,941 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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STAT4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene