ATP6V1C2 Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase C subunit family. Kidney and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - oxidative phosphorylation; Hydrolase
Chromosomal Location of Human Ortholog: 12|12 A1.1
Cellular Component:  proton-transporting V-type ATPase, V1 domain; vacuolar proton-transporting V-type ATPase, V1 domain
Molecular Function:  protein dimerization activity; proton transmembrane transporter activity; proton-exporting ATPase activity, phosphorylative mechanism; proton-transporting ATPase activity, rotational mechanism
Biological Process:  ATP hydrolysis coupled proton transport; ion transport; positive regulation of Wnt signaling pathway
Reference #:  Q99L60 (UniProtKB)
Alt. Names/Synonyms: 1110038G14Rik; Atp6c2; Atp6v1c2; ATPase, H+ transporting, lysosomal V1 subunit C2; ATPase, H+ transporting, V1 subunit C; ATPase, H+ transporting, V1 subunit C, isoform 2; OTTMUSP00000028152; V-ATPase subunit C 2; V-type proton ATPase subunit C 2; Vacuolar proton pump subunit C 2; VATC2
Gene Symbols: Atp6v1c2
Molecular weight: 48,350 Da
Basal Isoelectric point: 6.31  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene