STAT2 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component:  cytosol; nucleoplasm; plasma membrane
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; ubiquitin-like protein ligase binding
Biological Process:  cytokine-mediated signaling pathway; defense response to virus; JAK-STAT cascade; regulation of mitochondrial fission; regulation of protein phosphorylation; regulation of transcription by RNA polymerase II; type I interferon signaling pathway; viral process
Disease: Immunodeficiency 44
Reference #:  P52630 (UniProtKB)
Alt. Names/Synonyms: interferon alpha induced transcriptional activator; ISGF-3; MGC59816; p113; Signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT113; STAT2
Gene Symbols: STAT2
Molecular weight: 97,916 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein