SENP5 Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Belongs to the peptidase C48 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleolus; Protease; Sumo-specific protease
Chromosomal Location of mouse Ortholog: 16|16 B2
Cellular Component:  nucleolus; nucleus
Molecular Function:  cysteine-type peptidase activity; hydrolase activity; peptidase activity; ubiquitin-like protein-specific protease activity
Biological Process:  cell cycle; cell division; protein desumoylation; proteolysis
Reference #:  Q6NXL6 (UniProtKB)
Alt. Names/Synonyms: 6230429P13Rik; A730063F07Rik; AI851888; BB189556; DKFZp564O1016; OTTMUSP00000030730; Senp5; Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5; Smt3ip3; SUMO/sentrin specific peptidase 5; SUMO/sentrin specific protease 5; SUMO/Smt3-specific isopeptidase 3
Gene Symbols: Senp5
Molecular weight: 86,100 Da
Basal Isoelectric point: 9.16  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene