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SENP5
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Belongs to the peptidase C48 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease |
| Chromosomal Location of human Ortholog: 3q29 |
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Cellular Component:
nucleolus; nucleoplasm; nucleus
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Molecular Function:
deSUMOylase activity; protein binding; SUMO-specific endopeptidase activity
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Biological Process:
cell cycle; cell division; protein desumoylation; protein sumoylation
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Reference #:
Q96HI0
(UniProtKB)
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Alt. Names/Synonyms: DKFZp564O1016; FLJ42398; MGC27076; SENP5; Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5; SUMO specific peptidase 5; SUMO1/sentrin specific peptidase 5; SUMO1/sentrin specific protease 5
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Gene Symbols: SENP5
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Molecular weight:
86,693 Da
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Basal Isoelectric point:
9.3
Predict pI for various phosphorylation states
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