NAA40 N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A. In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence'. Acts as a negative regulator of apoptosis. May play a role in hepatic lipid metabolism. Belongs to the acetyltransferase family. NAA40 subfamily. Widely expressed; with the highest expression level in liver and the lowest expression in brain (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC 2.3.1.-
Chromosomal Location of mouse Ortholog: 19|19 A
Cellular Component:  centriolar satellite; cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  acyltransferase activity; histone H2A acetyltransferase activity; histone H4 acetyltransferase activity; N-acetyltransferase activity; peptide-serine-alpha-N-acetyltransferase activity; transferase activity
Biological Process:  histone H2A acetylation; histone H4 acetylation; lipid metabolic process; N-terminal protein amino acid acetylation
Reference #:  Q8VE10 (UniProtKB)
Alt. Names/Synonyms: 4931433E08Rik; AU023197; N(alpha)-acetyltransferase 40, NatD catalytic subunit; N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog; N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae); N-acetyltransferase 11; N-alpha-acetyltransferase 40; N-alpha-acetyltransferase 40, NatD catalytic subunit; N-alpha-acetyltransferase D; Naa40; Nalpha acetyltransferase 40; Nat; Nat11; NatD; natD catalytic subunit; Patt1; Protein acetyltransferase 1
Gene Symbols: Naa40
Molecular weight: 27,229 Da
Basal Isoelectric point: 7.03  Predict pI for various phosphorylation states
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NAA40

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Protein