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NAA40
N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A. In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence'. Acts as a negative regulator of apoptosis. May play a role in hepatic lipid metabolism. Belongs to the acetyltransferase family. NAA40 subfamily. Widely expressed; with the highest expression level in liver and the lowest expression in brain (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Acetyltransferase; EC 2.3.1.- |
| Chromosomal Location of mouse Ortholog: 19|19 A |
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Cellular Component:
centriolar satellite; cytoplasm; cytosol; nucleoplasm; nucleus
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Molecular Function:
acyltransferase activity; histone H2A acetyltransferase activity; histone H4 acetyltransferase activity; N-acetyltransferase activity; peptide-serine-alpha-N-acetyltransferase activity; transferase activity
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Biological Process:
histone H2A acetylation; histone H4 acetylation; lipid metabolic process; N-terminal protein amino acid acetylation
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Reference #:
Q8VE10
(UniProtKB)
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Alt. Names/Synonyms: 4931433E08Rik; AU023197; N(alpha)-acetyltransferase 40, NatD catalytic subunit; N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog; N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae); N-acetyltransferase 11; N-alpha-acetyltransferase 40; N-alpha-acetyltransferase 40, NatD catalytic subunit; N-alpha-acetyltransferase D; Naa40; Nalpha acetyltransferase 40; Nat; Nat11; NatD; natD catalytic subunit; Patt1; Protein acetyltransferase 1
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Gene Symbols: Naa40
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Molecular weight:
27,229 Da
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Basal Isoelectric point:
7.03
Predict pI for various phosphorylation states
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