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JARID1B
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. Belongs to the JARID1 histone demethylase family. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cancer Testis Antigen (CTA); Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 1 E4|1 58.24 cM |
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Cellular Component:
chromatin; cytosol; nucleoplasm; nucleus
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Molecular Function:
dioxygenase activity; DNA binding; histone binding; histone H3K4 demethylase activity; histone H3K4me/H3K4me2/H3K4me3 demethylase activity; metal ion binding; nucleic acid binding; oxidoreductase activity; protein binding; sequence-specific double-stranded DNA binding; transcription corepressor activity; zinc ion binding
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Biological Process:
branching involved in mammary gland duct morphogenesis; cellular response to leukemia inhibitory factor; chromatin organization; chromatin remodeling; mammary duct terminal end bud growth; negative regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of mammary gland epithelial cell proliferation; post-embryonic development; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of estradiol secretion; rhythmic process; single fertilization; uterus morphogenesis
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Reference #:
Q80Y84
(UniProtKB)
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Alt. Names/Synonyms: 2010009J12Rik; 2210016I17Rik; [histone H3]-trimethyl-L-lysine(4) demethylase 5B; AW556288; CT31; D1Ertd202; D1Ertd202e; Histone demethylase JARID1B; Jari; Jarid1b; jumonji, AT rich interactive domain 1B (Rbp2 like); Jumonji/ARID domain-containing protein 1B; Kdm5b; Kiaa4034; lysine (K)-specific demethylase 5B; Lysine-specific demethylase 5B; mKIAA4034; OTTMUSP00000018570; PLU; PLU-1; Plu1; PUT1; putative DNA/chromatin binding motif 1; Rb-B; Rb-Bp2; RBBP2H1A
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Gene Symbols: Kdm5b
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Molecular weight:
175,555 Da
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Basal Isoelectric point:
6.03
Predict pI for various phosphorylation states
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CST Pathways:
Histone Methylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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