JARID1B Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. Belongs to the JARID1 histone demethylase family. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1 E4|1 58.24 cM
Cellular Component:  cytosol; histone methyltransferase complex; nucleus
Molecular Function:  dioxygenase activity; DNA binding; histone binding; histone demethylase activity; histone demethylase activity (H3-dimethyl-K4 specific); histone demethylase activity (H3-K4 specific); histone demethylase activity (H3-trimethyl-K4 specific); metal ion binding; oxidoreductase activity; protein binding; sequence-specific double-stranded DNA binding; transcription corepressor activity; zinc ion binding
Biological Process:  branching involved in mammary gland duct morphogenesis; cellular response to leukemia inhibitory factor; chromatin organization; chromatin remodeling; histone H3-K4 demethylation; mammary duct terminal end bud growth; negative regulation of transcription, DNA-templated; oxidation-reduction process; positive regulation of gene expression; positive regulation of mammary gland epithelial cell proliferation; post-embryonic development; regulation of circadian rhythm; regulation of estradiol secretion; rhythmic process; single fertilization; uterus morphogenesis
Reference #:  Q80Y84 (UniProtKB)
Alt. Names/Synonyms: 2010009J12Rik; 2210016I17Rik; [histone H3]-trimethyl-L-lysine(4) demethylase 5B; AW556288; CT31; D1Ertd202; D1Ertd202e; Histone demethylase JARID1B; Jari; Jarid1b; jumonji, AT rich interactive domain 1B (Rbp2 like); Jumonji/ARID domain-containing protein 1B; Kdm5b; Kiaa4034; lysine (K)-specific demethylase 5B; Lysine-specific demethylase 5B; mKIAA4034; OTTMUSP00000018570; PLU; PLU-1; Plu1; PUT1; putative DNA/chromatin binding motif 1; Rb-B; Rb-Bp2; RBBP2H1A
Gene Symbols: Kdm5b
Molecular weight: 175,555 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene