RBBP7 Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: X|X F4
Cellular Component:  cytosol; ESC/E(Z) complex; nucleoplasm; nucleus; NuRD complex
Molecular Function:  protein binding; RNA binding
Biological Process:  cellular heat acclimation; chromatin organization; chromatin remodeling; DNA replication; negative regulation of cell growth; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated
Reference #:  Q60973 (UniProtKB)
Alt. Names/Synonyms: AA409861; AI173248; AU019541; BB114024; G1/S transition control protein-binding protein; Histone acetyltransferase type B subunit 2; Histone-binding protein RBBP7; mRbAp46; Nucleosome-remodeling factor subunit RBAP46; OTTMUSP00000018766; Rbap46; RBBP-7; Rbbp7; retinoblastoma binding protein 7; Retinoblastoma-binding protein 7; Retinoblastoma-binding protein p46
Gene Symbols: Rbbp7
Molecular weight: 47,790 Da
Basal Isoelectric point: 4.89  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation  |  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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RBBP7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA