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RBBP7
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator |
| Chromosomal Location of human Ortholog: Xp22.2 |
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Cellular Component:
ATPase complex; chromosome, telomeric region; cytosol; ESC/E(Z) complex; histone deacetylase complex; nucleoplasm; nucleus; NuRD complex; NURF complex; Sin3 complex
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Molecular Function:
histone binding; protein binding; RNA binding
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Biological Process:
brain development; cellular heat acclimation; chromatin remodeling; DNA replication; histone deacetylation; negative regulation of cell growth; negative regulation of cell migration; negative regulation of DNA-templated transcription; negative regulation of stem cell population maintenance; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of DNA-templated transcription; positive regulation of stem cell population maintenance; regulation of cell fate specification; regulation of DNA-templated transcription; regulation of stem cell differentiation; response to steroid hormone
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Disease: Spermatogenic Failure, X-linked, 9
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Reference #:
Q16576
(UniProtKB)
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Alt. Names/Synonyms: G1/S transition control protein-binding protein RbAp46; Histone acetyltransferase type B subunit 2; Histone-binding protein RBBP7; MGC138867; MGC138868; Nucleosome-remodeling factor subunit RBAP46; RB binding protein 7, chromatin remodeling factor; RBAP46; RBBP-7; RBBP7; retinoblastoma binding protein 7; Retinoblastoma-binding protein 7; Retinoblastoma-binding protein p46; retinoblastoma-binding protein RbAp46
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Gene Symbols: RBBP7
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Molecular weight:
47,820 Da
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Basal Isoelectric point:
4.89
Predict pI for various phosphorylation states
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CST Pathways:
Histone Methylation
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Protein Acetylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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