RBBP7 Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: Xp22.2
Cellular Component:  cytosol; ESC/E(Z) complex; nucleoplasm; nucleus; NuRD complex
Molecular Function:  protein binding; RNA binding
Biological Process:  cellular heat acclimation; CENP-A containing nucleosome assembly; DNA replication; negative regulation of cell growth; negative regulation of G0 to G1 transition; negative regulation of gene expression, epigenetic; negative regulation of transcription by RNA polymerase II; post-translational protein modification; regulation of signal transduction by p53 class mediator; response to steroid hormone
Reference #:  Q16576 (UniProtKB)
Alt. Names/Synonyms: G1/S transition control protein-binding protein RbAp46; Histone acetyltransferase type B subunit 2; Histone-binding protein RBBP7; MGC138867; MGC138868; Nucleosome-remodeling factor subunit RBAP46; RB binding protein 7, chromatin remodeling factor; RBAP46; RBBP-7; RBBP7; retinoblastoma binding protein 7; Retinoblastoma-binding protein 7; Retinoblastoma-binding protein p46; retinoblastoma-binding protein RbAp46
Gene Symbols: RBBP7
Molecular weight: 47,820 Da
Basal Isoelectric point: 4.89  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation  |  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA